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71.
Massimo Giusti Barbara Massa Margherita Balestra Paola Calamaro Stefano Gay Simone Schiaffino Giovanni Turtulici Simonetta Zupo Eleonora Monti Gianluca Ansaldo 《Journal of Zhejiang University. Science. B》2017,18(7):555-566
The cytology of 130 indeterminate nodules (Thy 3) was retrospectively reviewed according to the British Thyroid Association 2014 classification. Nodules were divided into Thy 3a (atypical features) and Thy 3f (follicular lesion) categories. Histology was available as a reference for 97 nodules. Pre-surgical evaluations comprised biochemical tests, color-Doppler ultrasonography (US), semi-quantitative elastography-US (USE), contrast-enhanced US (CEUS), and mutation analysis from cytological slides. Thyroid malignancy was the final diagnosis for 19% of surgically-treated nodules. No statistically significant difference in the risk of malignancy was found between Thy 3a (26%) and Thy 3f (14%) nodules. Histology of the Thy 3a and Thy 3f nodules showed a higher incidence of Hurtle cell adenomas in Thy 3f (29%) than in Thy 3a (3%) nodules (P=0.01). The only pre-surgical difference concerned the BRAF V600E mutation, which was positive in some Thy 3a but not in any Thy 3f nodules (P=0.04). Receiver-operating characteristic (ROC) analysis was used to obtain cut-off values from US (score), USE (ELX 2/1 strain index), and CEUS (time-topeak index and peak index) data. The cut-off values were similar for Thy 3a and Thy 3f nodules. Data showed that malignancy can be suspected if the US score is >2, ELX 1/2 strain index >1, time-to-peak index >1, and peak index <1. In a sub-group of 24 revised nodules (12 Thy 3a and 12 Thy 3f) with histology as a reference, the diagnostic power of cumulative pre-surgical analysis by means of US, USE, and CEUS showed high positive and negative predictive values (83% and 100%, respectively) for the presence of malignancy in Thy 3a and Thy 3f nodules. In conclusion, in our series of revised Thy 3 nodules, malignancy was low and displayed no significant differences between Thy 3a and Thy 3f categories. The use of cut-offs based on histology as a reference could reduce surgery. Our data support the conviction that, in mutation-negative Thy 3a and Thy 3f nodules, observation should be the first choice when not all instrumental results are suspect. 相似文献
72.
Synnöve Kekkonen–Moneta & Giovanni B Moneta 《British journal of educational technology : journal of the Council for Educational Technology》2002,33(4):423-433
This paper evaluates the effectiveness of Web–based, highly interactive, and multimedia–rich e–learning materials by comparing students' learning outcomes in the lecture and online versions of an introductory computing course. The course versions differed only in that face–to–face lectures were replaced with e–learning modules in the online course; the other course elements (laboratory sessions, use of computer–mediated communications, examinations) were the same. The e–learning trial took place at the Hong Kong University of Science and Technology, where the first author taught the lecture course to 105 students, and the online course to 180 and 129 students in the following semesters. The lecture and online students achieved comparable factual learning outcomes and the online students outperformed the lecture students in applied–conceptual learning. Findings suggest that the use of carefully designed interactive e–learning modules fosters higher–order learning outcomes. 相似文献
73.
Giovanni Gozzer 《Prospects》1990,20(1):9-19
Director of the National Office of Didactic Centres, Italian Department of Public Instruction. Founding director of the European Education Centre at Frascati (1959–74). Author of numerous publications on education in the world, notably the three volumes of Invisible Capital(1975–81). 相似文献
74.
Physicians’ willingness to share knowledge is a central antecedent of effective knowledge sharing within hospitals. This paper aims at supporting the micro-foundation of knowledge sharing with the identification of the factors that affect willingness to share and their classification according to a behavioural model grounded in the Theory of Planned Behaviour (TPB). The identification of antecedents and their classification is based on the review of the major contributions published on top tier and specialist journals. This study identifies 22 factors that affect physicians’ willingness to share. These factors are classified according to the TPB framework, which identifies three behavioural antecedents: attitude, subjective norm and perceived behaviour control. The organization of the factors allows appreciating the diffusion of knowledge-sharing behaviours as the result of three concurring perspectives: raising attention to the benefits of knowledge sharing, building up social pressures from relevant actors and designing appropriate organizational contingencies. 相似文献
75.
When two athletes meet inside the ropes of the boxing ring to fight, their cognitive systems have to respond as quickly as possible to a manifold of stimuli to assure victory. In the present work, we studied the pre-attentive mechanisms, which form the basis of an athlete’s ability in reacting to an opponent’s punches. Expert boxers, beginner boxers and people with no experience of boxing performed a Simon-like task where they judged the colour of the boxing gloves worn by athletes in attack postures by pressing two lateralised keys. Although participants were not instructed to pay attention to the direction of the punches, beginner boxers’ responses resembled a defence-related pattern, expert boxers’ resembled counterattacks, whereas non-athletes’ responses were not influenced by the unrelated task information. Results are discussed in the light of an expertise-related action simulation account. 相似文献
76.
Marika Arena Michela Arnaboldi Giovanni Azzone Paola Carlucci 《Higher Education Quarterly》2009,63(3):237-263
Central administrative services have recently received increasing attention from practitioners and academics due to the challenging need to both manage scarce resources and provide high-quality services. In this context, performance measurement systems (PMSs) may assume a central role, although an unresolved debate remains on the claimed benefits of accountability and the difficulties that have emerged in defining and managing proper measures. This paper contributes to this debate by presenting the results of a study in which a PMS for central administrative services has been developed and tested through an action research approach drawing on actor network theory. The experiment was carried out in 15 Italian universities and five areas of services were dealt with: student support, research support, accounting, human resources, and logistics and procurement. The highly participative method resulted in a comparable system with a complete set of cost and quality indicators across the participating universities. These data proved to be useful at managerial and policy level, providing insights on the presence of scale effects and on the relative importance of quality dimensions for users of services. Participating in the project encouraged the university staff to use indicators in decision making. 相似文献
77.
Nasser Abu Zeid Marco Balducci Francesco Bartocci Roberto Regni Giovanni Santarato 《Journal of Cultural Heritage》2010,11(2):220-227
The electrical resistivity tomography (ERT) represents one of the widely used geophysical techniques for the exploration of the subsurface. In the last few years, this method has been demonstrated to be an efficient reconnaissance tool not only for monitoring degradation status of walls and foundations of historical buildings, but also for imaging the spatial distribution of injected mortar, commonly employed for consolidation purposes. A 3D resistivity tomography survey was carried out on four selected wall portions of the historical church of Montepetriolo, Perugia, Central Italy. The obtained 3D resistivity distribution models before and after grouting provided suggestive images of the internal structure of the studied walls. Moreover, the spatial distribution of the zones being filled with mortar was determined quantitatively by scaling the post- to the preinjection resistivity values. Using a well known correlation between resistivity and porosity, established in the geophysical community, a further step towards a more quantitative assessment was attempted to indirectly determine the unit volumes of the injected mortar The obtained results were satisfactory and in some cases almost similar to the yard data. Furthermore, two flat-jack tests confirmed the local increment of the mechanical resistance of the studied left front (2) and right lateral (3) wall portions. 相似文献
78.
Leopoldina Fortunati Mauro Sarrica Giovanni Ferrin Sonia Brondi Furio Honsell 《The Information Society》2018,34(3):141-152
We investigate youths' conceptualization of social robots. Informed by Schudson's theory of the potency of the cultural object, we conducted two studies. The first study centered on essays on social robots written by bachelor's and master's students. The second study centered on prototypes of social robots built by small groups comprised of same students. The essays and prototypes were content analyzed. The results confirm that social robots embody all five dimensions that characterize cultural objects. However, to fully understand this peculiar cultural object, another dimension needs to be introduced: dynamicity. 相似文献
79.
80.
Technological paradigms and technological trajectories: A suggested interpretation of the determinants and directions of technical change 总被引：1，自引：0，他引：1
Giovanni Dosi 《Research Policy》1982,11(3):147-162
The procedures and the nature of “technologies” are suggested to be broadly similar to those which characterize “science”. In particular, there appear to be “technological paradigms” (or research programmes) performing a similar role to “scientific paradigms” (or research programmes). The model tries to account for both continuous changes and discontinuities in technological innovation. Continuous changes are often related to progress along a technological trajectory defined by a technological paradigm, while discontinuities are associated with the emergence of a new paradigm. One-directional explanations of the innovative process, and in particular those assuming “the market” as the prime mover, are inadequate to explain the emergence of new technological paradigms. The origin of the latter stems from the interplay between scientific advances, economic factors, institutional variables, and unsolved difficulties on established technological paths. The model tries to establish a sufficiently general framework which accounts for all these factors and to define the process of selection of new technological paradigms among a greater set of notionally possible ones.The history of a technology is contextual to the history of the industrial structures associated with that technology. The emergence of a new paradigm is often related to new “schumpeterian” companies, while its establishment often shows also a process of oligopolistic stabilization. 相似文献